Which of the following is not typically considered a characteristic of antidepressants?

In the context of antidepressants, high polarity is not typically regarded as a desirable characteristic. Antidepressants often require certain physical and chemical properties to facilitate their function and effectiveness.

Moderate pKa is significant because it influences the drug's interaction with biological systems, including its absorption and distribution in the body. A suitable pKa helps ensure that the drug remains in a form that can easily pass through cell membranes.

Sufficient lipophilic character is also important, as it allows the antidepressant to cross the blood-brain barrier effectively. Lipophilic drugs tend to have better bioavailability in the central nervous system, which is crucial for their therapeutic action.

Being organic bases is a common property of many antidepressants, allowing them to interact effectively with various receptors in the brain.

In contrast, high polarity could lead to poor membrane permeability and reduced central nervous system penetration, making it less beneficial for antidepressant characteristics. Hence, high polarity is not typically associated with the desirable traits of antidepressants.