Which method allows for the analysis of non-volatile analytes by vaporizing a solution through heat?

Thermospray Ionization is specifically designed for the analysis of non-volatile analytes by vaporizing a solution through the application of heat. This method combines the processes of nebulization and thermally induced vaporization to transform the sample into an aerosol. As the heated liquid passes through a nebulizer, it generates aerosols that are then heated even further to vaporize the non-volatile analytes effectively. This approach makes it particularly suitable for analyzing compounds that would not readily enter the gas phase under normal conditions, allowing for their subsequent detection in mass spectrometry.

In contrast, the other techniques mentioned function differently. Atmospheric Pressure Chemical Ionization and Atmospheric Pressure Photoionization focus more on ionization processes rather than vaporization of a sample by heat. They can be effective for particular types of analytes but do not specifically target the vaporization of non-volatile samples. Electrospray Ionization is designed for producing ions from polar liquids and is typically used for larger biomolecules or polar compounds rather than for vaporizing non-volatile solutions through heat.