Where are CB1 receptors primarily located in the body?

CB1 receptors are primarily located in both the central and peripheral nervous systems. These receptors are part of the endocannabinoid system and play a crucial role in various physiological processes. In the central nervous system, particularly in the brain, CB1 receptors are abundant and involved in modulating neurotransmitter release, affecting cognition, memory, and mood.

In addition to their presence in the brain, CB1 receptors are also found in peripheral tissues, including organs and the immune system. This widespread distribution is essential for the receptors' functions, as they influence a range of biological processes beyond just those originating from the brain. Thus, acknowledging their presence in both the central and peripheral systems is essential in understanding how cannabinoids affect the body holistically.