What type of cells are mainly associated with CB2 receptors?

The correct answer highlights that CB2 receptors are predominantly linked with immune cells and intestinal epithelium. CB2 receptors, part of the endocannabinoid system, are primarily expressed in the peripheral tissues, particularly in the immune system. They play a crucial role in modulating immune cell functions, such as cytokine production and immune response, which directly impacts inflammation and immune regulation.

In addition to immune cells, research indicates that CB2 receptors are also present in the intestinal epithelium, influencing gastrointestinal health and potentially affecting various functions, including motility and mucosal immunity. This connection underscores the importance of CB2 receptors beyond the central nervous system, illustrating their diverse role in maintaining homeostasis in both immune response and gut health.

The other options do not accurately represent the main associations of CB2 receptors. While central nervous system cells do express CB1 receptors more prominently, they are not the primary cells linked with CB2. Skeletal muscle cells and neuronal epithelial cells similarly have little to no established correlation with CB2 receptors, further supporting that the primary associations lie with immune cells and intestinal epithelial cells.