Aluminum toxicity has been linked to osteomalacia, which is a condition characterized by the softening of bones due to impaired mineralization. This occurs because aluminum can interfere with the metabolism of calcium and phosphate, essential minerals for healthy bone formation. When aluminum accumulates in the body, particularly in individuals with compromised kidney function, it can disrupt bone health, leading to osteomalacia.
While anemia, nephropathy, and neuropathy are also concerns associated with aluminum exposure, osteomalacia is specifically noted as a direct consequence of how aluminum affects bone mineralization. The relationship between aluminum and osteomalacia emphasizes the importance of monitoring aluminum levels, especially in individuals with conditions that predispose them to higher susceptibility, such as renal impairment.