Hallucinogens typically alter perception through which type of receptors?

Hallucinogens typically alter perception primarily through 5-HT receptors, which are serotonin receptors. These receptors are crucial in the functioning of the serotonin neurotransmitter system, which plays a vital role in mood, perception, and cognition. Many hallucinogens, such as LSD, psilocybin, and DMT, are known to have high affinity for certain subtypes of these receptors, particularly the 5-HT2A receptor. When hallucinogens bind to these receptors, they can induce alterations in sensory perception, mood, and thought processes, leading to the characteristic experiences associated with these substances.

The interaction with 5-HT receptors is fundamental in producing the psychedelic effects that characterize hallucinogens, as they modify the way information is processed in the brain, thus causing changes in perception, feelings, and overall consciousness. This mechanism delineates hallucinogens from other drug classes that may influence neurochemistry through dopamine, GABA, or NMDA receptors.